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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon Gamma-1B
supplement:
Tryptophan
Research Papers that Mention the Interaction
“ IFN-gamma induces expression of the enzyme indoleamine 2,3-dioxygenase (IDO), resulting in the degradation of intracellular pools of tryptophan , thereby depriving the organism of this essential growth nutrient.”
Pregnancy, indoleamine 2,3-dioxygenase (IDO) and chlamydial abortion: an unresolved paradox.“It is suggested that, in the presence of IFN-gamma , which depletes available tryptophan , there exist unique host-parasite interactions that may contribute to persistent chlamydial infection.”
“Resupplementation of L-tryptophan abrogated the inhibitory effect of IFN-gamma on the growth of staphylococci, hence confirming the activation of indoleamine 2,3-dioxygenase as being responsible for the induced bacteriostasis.”
“In addition, incubation of fibroblasts with IFN-gamma resulted in a marked increase in cellular indoleamine 2,3-dioxygenase (IDO) mRNA, a > 90% depletion of tryptophan , and a corresponding > 30-fold increase in the tryptophan metabolite kynurenine in the culture media.”
“ IFN-gamma induces the production of N-formyl-kynurenine from L-tryptophan in various cell types by the induction of the enzyme indoleamine 2,3-dioxygenase (IDO).”
“Thus, in some in vitro systems, antiproliferative effects of IFN-gamma are mediated by induced depletion of Trp.”
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