Possible Interaction: Interferon Gamma-1B and Tretinoin

“Our results indicate that IFN-alpha potently suppresses the abnormal IL-4 and IL-5 production, that IL-12 can correct the deficient IFN-gamma production and cell-mediated cytotoxicity, and that retinoids can enhance IFN-gamma and IL-12 production.”

“Optimal suppression is observed in the presence of 200 IU/ml IFN-gamma and 1 microM RA.”

“Our results demonstrated that ATRA suppressed NF-kappaB activity and prevented IkappaBalpha degradation in a dose-dependent way, inhibited IFN-gamma production and gene expression of granzyme B and NKp46.”

“In contrast, ATRA suppressed the production of IFN-gamma and TNF-alpha significantly.”

“Expression of mRNA for IL-12p35, IL-12p40, IFN-gamma in the cells that had been incubated with RA declined, but IL-10, IL-4 increased significantly.”

“ Retinoic acid with TNFalpha and IFN-gamma had a marked inhibitory effect (P<0.05) which was similarly reversed by increasing concentrations of IGFBP-3 antibody.”

“The present data support the hypothesis that the combination of TNFalpha and IFN-gamma with retinoic acid exert their anti-proliferative effect on HSG cells by reducing the mitogenic effect of IGF-I due to a shift in IGF-I from the free to the IGFBP-3-bound form.”

“ Retinoids and gamma-interferon ( IFN-gamma ) have been demonstrated to synergistically amplify growth inhibition in cultured breast cancer cells.”

“Since IFN-gamma enhances effects mediated by retinoids more than vice versa, we focused our investigations on the mRNA expression of cellular retinoic acid-binding proteins (CRABPs) and retinoic acid receptors (RARs), since these are the key molecules that mediate retinoid action.”

“Analysis of cellular … demonstrated that RA augmented levels of gene expression: (i) induced by IFN-alpha such as …'-oligoadenylate synthetase, mRNA 561 and mRNA 6-16; (ii) induced by IFN-gamma such as 2A and P56; and (iii) induced by …-alpha and IFN-gamma such as mRNA 1-8.”

“Co-treatment of NB-4 cells by IFN-gamma plus RA induced a sub-set of IFN-induced genes which were not induced by either IFN-gamma or RA alone.”

“At least an additive differentiation-inducing effect was found between IFN-gamma and 1-100 nM retinoic acid (RA).”

“These results, indicating that combinations of IFN-gamma and either RA or 1,25(OH)2D3 induce differentiation of U-937, may be of importance in combination biotherapy of leukemia.”

“These memory cells actively inhibited the TGF-beta-induced conversion of naive CD4(+) T cells through the synthesis of a set of cytokines (IL-4, IL-21, IFN-gamma ) whose expression was coordinately curtailed by RA.”