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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon Gamma-1B
supplement:
Resveratrol
Research Papers that Mention the Interaction
“…,resveratrol … IFN-gamma and TNF-alpha release from PBMC, but it did not cause inhibition at 10(-5) or 10(-7) M. The concomitant immune effects … study suggests that resveratrol, which is typically present in red wine at about 10(-5) M, is unlikely to cause inhibitory immune effects.”
Effects of resveratrol on lymphocyte proliferation and cytokine release.“When macrophages were primed with IFN-gamma, resveratrol suppressed the expression of HLA-ABC, HLA-DR, CD80, CD86 and inhibited production of TNF-alpha, IL-12, IL-6 and IL-1beta induced by LPS.”
“The results showed that in vitro exposure to resveratrol produces a biphasic effect on the anti-CD3/anti-CD28-induced development of both IFN-gamma- IL2- and IL4-producing CD8+ and CD4+ T cells, with stimulation at low resveratrol concentrations and suppression at high concentrations.”
“Furthermore, resveratrol enhanced IFN-gamma expression in CD8+ T cells both ex vivo and in vivo,leading to immune stimulation.”
Resveratrol induces the suppression of tumor-derived CD4+CD25+ regulatory T cells.“RESULTS RS ca n inhibit the proliferation and expression of IL-2 and IFN -gamma of T lymphocytes.”
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