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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon Gamma-1B
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“In the present study, we found that (-)-epigallocatechin-3-gallate (EGCG ) significantly up-regulated the mRNA expression of the Th1/Th2 cytokines including IL-2, IFN-gamma , IL-5 and IL-13 in Jurkat T cells.”
(-)-Epigallocatechin-3-gallate induces up-regulation of Th1 and Th2 cytokine genes in Jurkat T cells.“ Epigallocatechin gallate (EGCG), an inhibitor of STAT1-mediated signaling, and AG490, a Janus kinase (JAK) inhibitor, impaired P2X4-receptor mRNA up-regulation by IFN-gamma.”
“On the immunohistochemistry, EGCG also markedly diminished the expression of MIF, TNF-alpha and IFN-gamma.”
“The mRNA expression of MIF, TNF-alpha, IFN-gamma , IL-2 and IL-12 p40, but not of IL-4, IL-5 and IL-13 in the lesions was significantly reduced by EGCG (p<0.05).”
Epigallocatechin-3-gallate improves Dermatophagoides pteronissinus extract-induced atopic dermatitis-like skin lesions in NC/Nga mice by suppressing macrophage migration inhibitory factor.
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