Possible Interaction: Interferon-Alpha and Vitamin D

“… vitamin D supplementation increased the number of CD11c+ cells, … necrosis factor alpha [TNF-α], gamma interferon [ IFN-γ ], and interleukin-6 [IL-6]) and inducible nitric oxide synthase (iNOS), and enhanced the expression of … and glutamate-cysteine ligase modifier subunit), antimicrobial peptides (cathelicidin), and autophagy (ATG5 and beclin-1).”

“The results demonstrate that Vitamin D significantly inhibited the abilities of T lymphocytes to produce IFN-γ and proliferate in vitro (P≤0.05), but retained their ability to undergo degranulation, which is a maker for cytotoxicity of these cells.”

“ Vitamin D in airway epithelium decreases RSV induction of NF-kappaB-driven genes such as IFN-β and IP-10.”

“ Vitamin D inhibits IFN-γ and IL-17 production while inducing regulatory T cells.”

“The CC genotype of the Cys148Arg variant was also contributing to the lowered ARLTS1 expression status in lymphoblastoid cells from familial patients.”

“ Vitamin D attenuated the seasonal change in T cell-produced IFN-γ , suggesting a decrease in effector response which could be associated with inflammation.”

“ Vitamin D … IFN-γ by ~28% with mean ng/ml (SEM) for placebo vs vitamin D, respectively, for April 12.5(1.4) vs 10.0(1.…) vs 10.2(1.7) (p=0.02) and January 7.4(1.1) vs 6.0(1.1) (p=0.04).”

“Background: Seven weeks of high-dose vitamin D treatment decreases intestinal IL17A and IFN-γ mRNA expression in active Crohn’s disease (CD).”

“The results in indicated that serum sTREM-1, TNFα, IFNβ , IL-1β, and IL-6 levels were significantly increased in CC (HPV+) patients compared to healthy NILM controls.”

“ Vitamin D may also attenuate interferon gamma ( IFNγ ) and interleukin-6 (IL-6) inflammatory responses, both potent predictors of poorer outcome in critically-ill ventilated patients including those with Covid-19.”

“Treatment with sitagliptin alone or in combination with VitD3 reduced the production of IFN-γ in the patients.”