supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Interferon-Alpha
supplement:
Vitamin A
Research Papers that Mention the Interaction
“ Retinol reduced IFNγ in GO and control fibroblasts.”
Antioxidant effects of β-carotene, but not of retinol and vitamin E, in orbital fibroblasts from patients with Graves’ orbitopathy (GO)“ IFN-γ gene expression in cells activated with ox-LDL in healthy control subjects and patients taking vitamin A , was reduced 0.43 (p = 0.0001) and 0.41 (p = 0.001) respectively, but in placebo patients was increased 2.2-fold (p = 0.959).”
“However, high concentration of VA had an inhibitory effect on the secretion of IL-4 as well as on the IFN-γ.”
“ VA could inhibit the secretion of IFN-γ and increase the IL-4 level in MP-induced A549 cells.”
“Furthermore, vitamin A supplementation was significantly associated with an increased ratio of mitogen‐induced proinflammatory cytokine ( IFN‐γ ) to anti‐inflammatory cytokine (IL‐10) during pregnancy and in the postpartum period.”
“Furthermore, VA pretreatment was also demonstrated to upregulate MHCII expression in dendritic cells (DCs), downregulate Th1 and Tregs, and downregulate TNF-α and IFN-γ production.”
Modulation of anti-malaria immunity by vitamin A in C57BL/6J mice infected with heterogenic plasmodium.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback