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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Interferon-Alpha and Vitamin A

Research Papers that Mention the Interaction

Retinol reduced IFNγ in GO and control fibroblasts.
Journal of Endocrinological Investigation  •  2017  |  View Paper
IFN-γ gene expression in cells activated with ox-LDL in healthy control subjects and patients taking vitamin A , was reduced 0.43 (p = 0.0001) and 0.41 (p = 0.001) respectively, but in placebo patients was increased 2.2-fold (p = 0.959).
Immunological investigations  •  2015  |  View Paper
However, high concentration of VA had an inhibitory effect on the secretion of IL-4 as well as on the IFN-γ.
VA could inhibit the secretion of IFN-γ and increase the IL-4 level in MP-induced A549 cells.
Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban  •  2008  |  View Paper
Furthermore, vitamin A supplementation was significantly associated with an increased ratio of mitogen‐induced proinflammatory cytokine ( IFN‐γ ) to anti‐inflammatory cytokine (IL‐10) during pregnancy and in the postpartum period.
Clinical and experimental immunology  •  2006  |  View Paper
Furthermore, VA pretreatment was also demonstrated to upregulate MHCII expression in dendritic cells (DCs), downregulate Th1 and Tregs, and downregulate TNF-α and IFN-γ production.
International immunopharmacology  •  2019  |  View Paper