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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Interferon-Alpha
supplement:
Tyrosine
Research Papers that Mention the Interaction
“IFN-β suppressed insulin-induced tyrosine phosphorylation of IRS-1 without affecting its expression, whereas IFN-γ reduced both the protein level and tyrosine phosphorylation.”
Both type I and II IFN induce insulin resistance by inducing different isoforms of SOCS expression in 3T3-L1 adipocytes.“Our results indicate that Y and/or I at position 86 and Y at position 90 are very important in antiproliferative activity of human IFN-α.”
“Consistently, tyrosine phosphorylation levels of Stat1 upon IFN-γ treatment and, to a lesser extent, upon IFN-α stimulation were markedly elevated in mutant cells.”
“Binding of alpha interferon (IFNalpha) to its receptors induces rapid tyrosine phosphorylation of the receptor subunits IFNaR1 and IFNaR2, the TYK2 and JAK1 tyrosine kinases, and the Stat1 and Stat2 transcription factors.”
“Interferon‐alpha IFN alpha ) induces rapid tyrosine phosphorylation of its receptors, two JAK kinases and three STAT transcription factors.”
“Specifically, the tyk2 gene is shown to encode a 135-kDa protein which is rapidly phosphorylated on tyrosine in response to interferon-alpha treatment.”
“Furthermore, IFN-α enhanced tyrosine phosphorylation of Stat1 and Stat2.”
“In human lymphoid cell lines, IFNα induced tyrosine phosphorylation of multiple cytosolic proteins in a time- and concentration-dependent manner.”
“ IFN-alpha enhanced tyrosine phosphorylation of STAT1, STAT3, STAT4, STAT5a, and STAT5b.”
“Further, IFN‐γ induced tyrosine phosphorylation of JAK2 in eosinophils, as indicated by Western blot analysis.”
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