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“PEG-IFN-&agr; has a similar influence on … IFN-&agr;. If a lowered availability of TRP and a consequent decrease of serotonergic … mechanism underlying neuropsychiatric side-effects of IFN-&agr ;, patients on PEG-IFN-&agr; are not at a lower … neuropsychiatric side-effects as patients on conventional IFN-&agr;.”
“We conclude that, like conventional IFN-&agr ;, PEG-IFN-&agr; lowers TRP concentrations and decreases the availability of TRP to the CNS.”
“Immunochemotherapy with IFN-alpha (1) significantly increased the MADRS and HAM-A scores and serum kynurenine concentrations and (2) significantly reduced plasma tryptophan and serum 5-HT concentrations.”
Journal of clinical psychopharmacology • 2002 | View Paper
“The available data indicate that V and W can inhibit the production of IFNα/β in response to various stimuli, while the P, V, and W proteins also block the ability of IFNs to signal and induce an antiviral state in cells.”
The Southeast Asian journal of tropical medicine and public health • 2009 | View Paper
“Inhibition of IDO1 activity in IFN-γ treated cultures by 1-methyl-L-tryptophan, a … inhibitor of IDO1, resulted in partial restoration of infection index; while excessive supplementation of L-tryptophan … IFN-γ treated cultures raised the index to an even higher level than that of the untreated ones.”
PLoS neglected tropical diseases • 2012 | View Paper
“Further, tryptophan supplementation and RNA interference directed against GCN2 inhibited IFN-γ –induced autophagy.”
“Our results indicate that IFN-γ promotes tryptophan depletion, activates the eIF2α kinase general control nonderepressible-2 (GCN2), and leads to an increase in the autophagic flux.”
“ IFNalpha treatment is reported to produce: 1) a decrease in tryptophan availability for serotonin synthesis, 2) a decrease in the 5-HIAA level in the LCR, and 3) a modification of the central serotoninergic receptors.”
“ IFN‐γ has been reported to inhibit the chlamydial replication in vitro in part by depleting intracellular levels of tryptophan in a dose‐dependent manner.”
“ Trp showed relatively weak direct scavenging activity but antagonized IFN-γ against the suppression of complex I. In addition, Trp increased the expression of the Nrf2-dependent antioxidant genes NQO1, HO-1 and GCS in hepatocytes both in vitro and in vivo.”