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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Interferon-Alpha and Tryptophan

Research Papers that Mention the Interaction

PEG-IFN-&agr; has a similar influence on … IFN-&agr;. If a lowered availability of TRP and a consequent decrease of serotonergic … mechanism underlying neuropsychiatric side-effects of IFN-&agr ;, patients on PEG-IFN-&agr; are not at a lower … neuropsychiatric side-effects as patients on conventional IFN-&agr;.
We conclude that, like conventional IFN-&agr ;, PEG-IFN-&agr; lowers TRP concentrations and decreases the availability of TRP to the CNS.
Anti-cancer drugs  •  2004  |  View Paper
Immunochemotherapy with IFN-alpha (1) significantly increased the MADRS and HAM-A scores and serum kynurenine concentrations and (2) significantly reduced plasma tryptophan and serum 5-HT concentrations.
Journal of clinical psychopharmacology  •  2002  |  View Paper
The available data indicate that V and W can inhibit the production of IFNα/β in response to various stimuli, while the P, V, and W proteins also block the ability of IFNs to signal and induce an antiviral state in cells.
Current topics in microbiology and immunology  •  2012  |  View Paper
Five peptides from TRAP and CTRP antigens significantly increased IFN-y responses of 1/9 in malaria-exposed volunteers.
The Southeast Asian journal of tropical medicine and public health  •  2009  |  View Paper
Inhibition of IDO1 activity in IFN-γ treated cultures by 1-methyl-L-tryptophan, a … inhibitor of IDO1, resulted in partial restoration of infection index; while excessive supplementation of L-tryptophan … IFN-γ treated cultures raised the index to an even higher level than that of the untreated ones.
PLoS neglected tropical diseases  •  2012  |  View Paper
Further, tryptophan supplementation and RNA interference directed against GCN2 inhibited IFN-γ –induced autophagy.
Our results indicate that IFN-γ promotes tryptophan depletion, activates the eIF2α kinase general control nonderepressible-2 (GCN2), and leads to an increase in the autophagic flux.
The Journal of Immunology  •  2012  |  View Paper
IFNalpha treatment is reported to produce: 1) a decrease in tryptophan availability for serotonin synthesis, 2) a decrease in the 5-HIAA level in the LCR, and 3) a modification of the central serotoninergic receptors.
L'Encephale  •  2005  |  View Paper
IFN-γ caused a decrease in tryptophan concentration on both sides of the epithelium.
The Journal of Immunology  •  2004  |  View Paper
IFN‐γ has been reported to inhibit the chlamydial replication in vitro in part by depleting intracellular levels of tryptophan in a dose‐dependent manner.
Electrophoresis  •  1999  |  View Paper
Trp showed relatively weak direct scavenging activity but antagonized IFN-γ against the suppression of complex I. In addition, Trp increased the expression of the Nrf2-dependent antioxidant genes NQO1, HO-1 and GCS in hepatocytes both in vitro and in vivo.
Amino Acids  •  2016  |  View Paper
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