Possible Interaction: Interferon-Alpha and Taurine

“Our results revealed that 1) the use of HR-MAS NMR is ideally … conditioned media without extraction procedures; and 2) a 72 h exposure to IFN-α2 increases the level of metabolites … myo-inositol, scyllo-inositol, taurine and glycerophosphorylcholine) balances in neuron-like … and glutamine in their growth media.”

“Additional experiments using isolated islets from Swiss mice showed that 3 mM TAU prevented the reduction in insulin secretion induced by 12 h incubation with IL1-β or IL1-β + IFN-γ.”

“… taurine markedly decreased the level of 17 … factor (GM-CSF), interferon-gamma ( IFN-γ ), IL-1α, IL-1β, IL-4, IL-5, IL-6, IL-10, IL-12p70, IL-13, IL-17, …-α), vascular endothelial growth factor (VEGF), and only increased the level of MIP-1α in a week.”

“Combined taurine and peginterferon-alpha 2b further reduced fibrosis and increased activated stellate cell apoptosis, but could not improve oxidative stress more than taurine alone.”

“ Peginterferon-alpha 2b in combination with taurine seems to be an antifibrotic strategy.”

“Mutagenesis with ethylmethylsulfonic acid (EMS), which can induce point mutations in DNA, increases the frequency of resistance to IFN-alpha 20 to 40-fold.”

“Our results revealed that 1) the use of HR-MAS NMR is ideally … their conditioned media without extraction procedures; and 2) a 72 h exposure to IFN-α2 increases the level of … asmyo-inositol, scyllo-inositol, taurine and glycerophosphorylcholine) balances in neuron-like … and glutamine in their growth media.”