Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Interferon-Alpha and Silymarin

Research Papers that Mention the Interaction

Studies in vivo using a model of progressive pulmonary TB … infected with drug-sensitive or MDR mycobacteria have shown that Sm induces significant expression … cytokines such as IFN-γ and IL-12 as well as TNFα, which produce significant … administered alone and apparently have a synergistic effect with chemotherapy.
PloS one  •  2019  |  View Paper
Additionally, IFN-γ production by Th1 cells … in newly diagnosed patients; however, in IFN-β treated … silymarin , IFN-γ concentration was decreased at concentrations of 100 and 150 μM, and after 120 h, … observed in the IFN-γ level at a concentration of 100 μM in comparison with DMSO.
Inflammation  •  2018  |  View Paper
Results of this part showed that silymarin significantly decreased IFNγ , RORγt and IL-17 gene expressions and upregulated Foxp3, TGF-β and IL-10 mRNA.
DARU Journal of Pharmaceutical Sciences  •  2018  |  View Paper
Also, the frequency of Treg cells after treatment with SM plus IFN-β was significantly increased compared to the placebo group (p < 0.05).
International immunopharmacology  •  2021  |  View Paper