Allen Institute for Artificial Intelligence
supp.ai logo
supp.ai

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Interferon-Alpha and Selenium

supplement:

Selenium

Research Papers that Mention the Interaction

Moreover, Se reduced the expression of IL-6, IFN-γ , IL-17A, IL-21, T-bet, and RORγt (P < 0.05 each), but enhanced the expression of IL-10 and Foxp3 (P < 0.05 each).
World journal of gastroenterology  •  2017  |  View Paper
Significant correlations were found between SE induced upregulation of mRNA expression for ifn-γ , il-17, il-22, ip-10, and serum level of antistreptolysin O in psoriatic patients.
The Journal of investigative dermatology  •  2013  |  View Paper
The IFN-γ mRNA expression was reduced in the groups treated with the medications ( Se , C.H., and C.H. + Se).
Clinical oral investigations  •  2020  |  View Paper
However, selenium treatment diminished activations of TRPM2, cytokine, Casp-3, and Casp-9, and levels of lipid peroxidation and mitochondrial ROS production in the microglia that were treated with IFNγ.
The apoptotic, inflammatory, and oxidant actions of IFNγ are modulated through TRPM2 inhibition by the Se treatment
Metabolic brain disease  •  2020  |  View Paper
LPS increased (P < 0.05) mRNA profiles … genes in cells, while short-time Se pretreatment modestly reversed (P < 0.05) the LPS-induced upregulation of 7 genes (COX-2, ICAM-…-6, IL-10, iNOS, and MCP-1) and further increased (P < 0.05) expression of IFN-β and … cells.
Biological trace element research  •  2018  |  View Paper
SE reduced the increased MPO activity in liver and TNF-α, IL-6, IFN-γ contents in serum, and blocked the decrease in IκB expression and subsequent increase in phosphorylation and nuclear translocation of p65 induced by EF.
Yao xue xue bao = Acta pharmaceutica Sinica  •  2016  |  View Paper
However, Se only regulated the expression of TNF-α and IFN-γ , and PAMK influenced more cytokines in immune organs.
The results showed that Se specifically regulated the TNF-α and IFN-γ pathways.
Biological Trace Element Research  •  2015  |  View Paper
It was concluded that 0.… and 0.8 mg/kg Se could increase the decreased percentages of peripheral blood T-… subsets and the contents of serum IL-2 and IFN-γ induced by 0.3mg/kg AFB1 in the diets, and cellular immune function could be improved in chickens.
Research in veterinary science  •  2013  |  View Paper
Our results suggest that selenium nanoparticle administration can result in considerable induction of the Th1 platform of immune response through the elevation of IFN-γ and IL-12 and may be a cause for better prognosis in mice with tumors.
Biological Trace Element Research  •  2012  |  View Paper