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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon-Alpha
supplement:
Selenium
Research Papers that Mention the Interaction
“Moreover, Se reduced the expression of IL-6, IFN-γ , IL-17A, IL-21, T-bet, and RORγt (P < 0.05 each), but enhanced the expression of IL-10 and Foxp3 (P < 0.05 each).”
Sodium selenite ameliorates dextran sulfate sodium-induced chronic colitis in mice by decreasing Th1, Th17, and γδT and increasing CD4(+)CD25(+) regulatory T-cell responses“Significant correlations were found between SE induced upregulation of mRNA expression for ifn-γ , il-17, il-22, ip-10, and serum level of antistreptolysin O in psoriatic patients.”
“The IFN-γ mRNA expression was reduced in the groups treated with the medications ( Se , C.H., and C.H. + Se).”
“However, selenium treatment diminished activations of TRPM2, cytokine, Casp-3, and Casp-9, and levels of lipid peroxidation and mitochondrial ROS production in the microglia that were treated with IFNγ.”
“The apoptotic, inflammatory, and oxidant actions of IFNγ are modulated through TRPM2 inhibition by the Se treatment”
Selenium prevents interferon-gamma induced activation of TRPM2 channel and inhibits inflammation, mitochondrial oxidative stress, and apoptosis in microglia“LPS increased (P < 0.05) mRNA profiles … genes in cells, while short-time Se pretreatment modestly reversed (P < 0.05) the LPS-induced upregulation of 7 genes (COX-2, ICAM-…-6, IL-10, iNOS, and MCP-1) and further increased (P < 0.05) expression of IFN-β and … cells.”
“ SE reduced the increased MPO activity in liver and TNF-α, IL-6, IFN-γ contents in serum, and blocked the decrease in IκB expression and subsequent increase in phosphorylation and nuclear translocation of p65 induced by EF.”
“However, Se only regulated the expression of TNF-α and IFN-γ , and PAMK influenced more cytokines in immune organs.”
“The results showed that Se specifically regulated the TNF-α and IFN-γ pathways.”
“It was concluded that 0.… and 0.8 mg/kg Se could increase the decreased percentages of peripheral blood T-… subsets and the contents of serum IL-2 and IFN-γ induced by 0.3mg/kg AFB1 in the diets, and cellular immune function could be improved in chickens.”
“Our results suggest that selenium nanoparticle administration can result in considerable induction of the Th1 platform of immune response through the elevation of IFN-γ and IL-12 and may be a cause for better prognosis in mice with tumors.”
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