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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Interferon-Alpha and S-Adenosylmethionine

Research Papers that Mention the Interaction

Furthermore, SAM enhances the IFN-α antiviral activity and protects against hepatic ischemia-reperfusion injury during hepatectomy in HCC patients with chronic hepatitis B virus (HBV) infection.
Medicina  •  2019  |  View Paper
By improving STAT1 methylation, SAM can enhance the antiviral effect of IFN-alpha.
Combined with IFN-alpha, SAM treatment effectively improved STAT1 methylation and attenuated STAT1-PIAS1 binding, followed by increased PKR and 2',5'-OAS mRNA expression, thus significantly reducing the HBsAg, HBeAg protein levels and HBV DNA load in the supernatant of HepG2.2.15 cells.
The potential improvement of S-adenosylmethionine SAM ) in the antiviral effect of IFN-alpha was also investigated.
Antiviral research  •  2010  |  View Paper
Furthermore, the antiviral effect of IFNα in cell culture could be significantly enhanced by the addition of AdoMet and betaine.
Hepatology  •  2006  |  View Paper