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Last Updated: 3 years ago

Possible Interaction: Interferon-Alpha and Quercetin

Research Papers that Mention the Interaction

Quercetin upregulated IFN-α and IFN-β expression through activating RIG-I promoter in B16 cells.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2020  |  View Paper
Thus, barrier disturbance in late distal colon specimens induced by TNF‐α and IFN‐γ could be partially prevented by coincubation with quercetin.
Annals of the New York Academy of Sciences  •  2012  |  View Paper
Treatment with 5 and 10 μM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-γ priming and before poly (dA:dT)-induced AIM2 activation.
Biochemical and biophysical research communications  •  2018  |  View Paper
Our findings suggest that quercetin up-regulates IRGs, IFNα , and down-regulates TGFβ mRNA expressions which may contribute to further reducing number of viremic pigs and HP-PRRSV viremia which were conferred by PRRSV-1 MLV vaccine.
Vaccine  •  2020  |  View Paper
Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p‐NFκB, p‐ERK1/2, COX2, TNFα, IL‐1β, IL‐2Rα, IFNγ and IL‐4 and upregulated nuclear Nrf2.
Experimental dermatology  •  2015  |  View Paper
Rutin had no effect on splenocytes or murine T cells in vitro, while its aglycone, quercetin , exhibited a concentration dependent inhibition of proinflammatory cytokines, including IFNγ.
Pharmacological research  •  2014  |  View Paper
Additionally, quercetin blocked inflammatory mediators HMGB-1 and IFN-γ , inhibiting activation of the NF-κB/TLR-4 axis.
Canadian journal of physiology and pharmacology  •  2021  |  View Paper
Furthermore, quercetin also sensitized the antiproliferative effect of IFN-α on hepatocellular carcinoma HepG2 and Huh7 cells.
Quercetin warrants further investigation as a novel therapeutic method to enhance the efficacy of IFN-α/β.
The results suggested that quercetin potentiated the inhibitory effect of IFN-α on cancer cell proliferation through activation of JAK/STAT pathway signaling by inhibiting SHP2.
Oncotarget  •  2017  |  View Paper