Possible Interaction: Interferon-Alpha and Quercetin

“ Quercetin upregulated IFN-α and IFN-β expression through activating RIG-I promoter in B16 cells.”

“Thus, barrier disturbance in late distal colon specimens induced by TNF‐α and IFN‐γ could be partially prevented by coincubation with quercetin.”

“Treatment with 5 and 10 μM of Quercetin inhibited the poly (dA:dT)-induced secretion of IL-18 after IFN-γ priming and before poly (dA:dT)-induced AIM2 activation.”

“Our findings suggest that quercetin up-regulates IRGs, IFNα , and down-regulates TGFβ mRNA expressions which may contribute to further reducing number of viremic pigs and HP-PRRSV viremia which were conferred by PRRSV-1 MLV vaccine.”

“Furthermore, quercetin treatment downregulated cytoplasmic HMGB1, RAGE, nuclear p‐NFκB, p‐ERK1/2, COX2, TNFα, IL‐1β, IL‐2Rα, IFNγ and IL‐4 and upregulated nuclear Nrf2.”

“Rutin had no effect on splenocytes or murine T cells in vitro, while its aglycone, quercetin , exhibited a concentration dependent inhibition of proinflammatory cytokines, including IFNγ.”

“Additionally, quercetin blocked inflammatory mediators HMGB-1 and IFN-γ , inhibiting activation of the NF-κB/TLR-4 axis.”

“Furthermore, quercetin also sensitized the antiproliferative effect of IFN-α on hepatocellular carcinoma HepG2 and Huh7 cells.”

“ Quercetin warrants further investigation as a novel therapeutic method to enhance the efficacy of IFN-α/β.”

“The results suggested that quercetin potentiated the inhibitory effect of IFN-α on cancer cell proliferation through activation of JAK/STAT pathway signaling by inhibiting SHP2.”