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Last Updated: 2 years ago

Possible Interaction: Interferon-Alpha and Progesterone

Research Papers that Mention the Interaction

We report that exposure of maternal T cells to progesterone at physiological doses induced a unique skewing of the cytokine production profile of CD4+ and CD8+ T cells, with reductions not only in potentially deleterious IFN‐γ and TNF‐α production but also in IL‐10 and IL‐5.
European journal of immunology  •  2015  |  View Paper
Progesterone and its metabolites reduced TNF-α and IFN-γ production in CD4+ and CD8+ T cells.
Scientific reports  •  2021  |  View Paper
In contrast, mice lacking IFN-λ signaling sustain greater FRT infection when progesterone is administered.
Nature Communications  •  2019  |  View Paper
Progesterone and dydrogesterone significantly down-regulated the secretion of the Th1 cytokines IFN-α and TNF-γ, and the Th17 cytokine IL-17A, and IL-23.
Journal of reproductive immunology  •  2020  |  View Paper
Progesterone has been shown to stimulate T regulatory cell (Treg) differentiation, restrain Th17 responses but enhance interferon-alpha (IFN-a) pathways (10, 13, 18), which all together could be of particular importance for keeping the viral replication under control, but without excessive and self-reinforcing inflammation.
Journal of applied physiology  •  2020  |  View Paper
A significant decrease in IFNγ and increase in IL-10 in endocervical fluid was seen when the values were compared before and after progesterone treatment.
Journal of reproductive immunology  •  2013  |  View Paper
Moreover, progesterone stimulation prior to IFN-α treatment attenuated the Jak/STAT pathway, which was reflected by decreased expression of MxA in females.
Progesterone decreased the inducing effect of IFN-α on TLR-7 expression in both males and females.
Archives of Virology  •  2013  |  View Paper
These data demonstrate that increased progesterone impairs immune protective functions of antigen-non-specific CD8 Tm cells via inducing IFN-γ gene hypermethylation.
PLoS pathogens  •  2017  |  View Paper
Progesterone treatment of the cells significantly inhibited the ability of IFN-τ to induce apoptosis (14.6%) compared with IFN-τ alone (33.6%; P < 0.05).
These data demonstrate that IFN-τ can induce apoptosis in bovine uterine epithelial cells and that this effect is modulated by progesterone.
Biology of reproduction  •  2003  |  View Paper
IFN-tau alters uterine release of PGF2 alpha' which results in rescue of the corpus luteum and continued release of progesterone.
Journal of reproduction and fertility. Supplement  •  1999  |  View Paper
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