Possible Interaction: Interferon-Alpha and Ovalbumin

“Both IFNγ and IL‐17 stimulated the uptake and processing of ovalbumin (OVA) by mouse podocytes, resulting in presentation of OVA antigen peptide on the cell surface.”

“The level of IFN-γ and IL-4 in the splenocytes was also upregulated when in vitro stimulated with OVA257-264 or OVA.”

“Neutrophils incubated in the presence of IFN-γ showed enhanced phagocytosis in response to zymosan, opsonized zymosan or precipitated immune complexes of IgG and ovalbumin.”

“ OVA stimulation decreased the splenocyte proliferation index and IFN-γ secretion in the CD4+/OVA/ChM group compared to the OVA group.”

“Moreover, in Sirt1 sensitized mice, IFNγ secretion by donor T cells was enhanced when stimulated with OVA in vitro, but there was no change in IL-17A (Fig. 1c).”

“The ratio of IFN-γ to IL-4 both in the OVA and vaccine plus OVA group was lower than that in the control group (p < 0.01).”

“The mRNA expression of IFN-γ and IL-13 in lung tissues and IL-4 in lymph nodes was significantly increased by both OVA and Ef-OVA compared with PBS and were not significantly different between OVA and Ef-OVA.”

“LPS and OVA pretreatment reduced IL-6 and IFN-γ mRNA expression and increased IL-10 mRNA expression compared with controls.”

“In addition, when IFN-treated BECs bearing class II molecules were pulsed with ovalbumin (OVA), they significantly stimulated the proliferation of OVA-sensitized T cells, whereas cells that were not treated with IFN-γ but were pulsed with OVA did not do so.”

“Moreover, IFN‐γ increased the presentation of cytosolic OVA , demonstrating differences between the presentation of cytosolic Ag versus exogenous Ag with MHC class I. Finally, some lines constitutively processed and presented exogenous OVA with MHC class II while others only presented after stimulation with IFN‐γ.”