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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Interferon-Alpha
supplement:
Methylselenocysteine
Research Papers that Mention the Interaction
“The veto function of both MSC lines was enhanced in escalating IFN-γ environments.”
Immunogenicity and Immunomodulatory Properties of Umbilical Cord Lining Mesenchymal Stem Cells“ IFN-γ inhibited proliferation and altered human and mouse MSC neural, adipocytic and osteocytic differentiation via the activation of IDO.”
“Importantly, CsA exposure to IFNγ pre-stimulated MSC before administration, significantly enhanced the potency of MSCs in a human relevant humanised mouse model of acute Graft versus Host Disease.”
“Both MSC can inhibit lymphocyte proliferation and suppress IFN-γ secretion induced by PHA in vitro.”
“Upon IFNγ prelicensing, both MSC populations inhibit T-cell effector functions.”
“For both T and B cells, MSC co-colture induced a statistically significant increase in IL-10 and TGFβ and decrease of GM-CSF and IFNγ , as compared with MV incubation.”
“In vitro, IFNγ significantly increased MSC proliferation, a response mediated by Shh that was blocked by 5E1 antibody.”
“The MSC population collected from bone marrow of PBS- or IFNγ-treated mice showed that IFNγ significantly increased the percentage of all MSC cell lines in S phase, with the exception of the stMSCsShhKO cells.”
“We tested the hypothesis that IFNγ drives MSC proliferation and recruitment, a response mediated by Shh signaling.”
Sonic Hedgehog Mediates the Proliferation and Recruitment of Transformed Mesenchymal Stem Cells to the Stomach“In a related article, Liu et al. investigated how interferon-gamma IFN-γ ) treatment can influence the metabolic state of MSC to promote immunomodulatory properties [5].”
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