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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon-Alpha
supplement:
Melatonin
Research Papers that Mention the Interaction
“Furthermore, melatonin enhances splenic interleukin (IL)-10 expression in regulatory T cells by inducing IL-27 expression in the splenic DC; it also suppresses the expression of IFN-γ , IL-17, IL-6, and CCL20 in the CNS and inhibits antigen-specific T cell proliferation.”
Melatonin enhances interleukin-10 expression and suppresses chemotaxis to inhibit inflammation in situ and reduce the severity of experimental autoimmune encephalomyelitis.“ Melatonin reduced IL1β and HA in GO and control fibroblasts, and IFNγ only in GO fibroblasts.”
“ MEL at 10 mg/kg alleviated simple and associative recognition memory dysfunction and anhedonia, along with reduced oxidative stress, enhanced glutathione and complex III, and reduced NLRP3 inflammasomes, IL-18, TNF-α, and IFN-γ.”
Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus“…,melatonin supplementation inverted the SD-induced the decline of antioxidant enzyme activities (…-AOC and CAT etc) and anti-inflammatory cytokines (IL-10 and IFN-γ ) and the increase of oxidative product MDA, pro-inflammatory cytokines (IL-6 and TNF-α), p-P65 and p-IκB proteins in the SI.”
“Interferon gamma IFN‐γ ), on the other hand, increases melatonin synthesis.”
“However, the dose of 100µM melatonin caused a decrease in levels of IFN-γ in both thymocyte media and an increase in the concentration of IL-10 in Concanavalin A-stimulated thymocytes.”
“In conclusion, our results indicated a relationship between age and the development of EAE since a negative impact was found for melatonin on EAE recovery of young rats by enhancing IFN‐γ , the ratio of Th1/Th2 cells, and astrocyte activation, which seems to delay the remyelination process.”
“Although serum IL-1β, IL-6, IL-18, TNF-α, and IFN- γ levels have decreased in treatment group following melatonin administration, this decrement was statistically significant for serum IL-18, TNF-α, and IFN- γ parameters compared with the IR group.”
“ Melatonin decreased the augmented circulating levels of IL‐1β, IL‐6, TNF‐α, IFN‐γ , and CRP seen in obese rats and restored the depressed levels of IL‐4 and IL‐10.”
“ Melatonin attenuated the increased levels of JAK2 and STAT1 activation as well as IFN‐β , and ZnPP reversed these inhibitory effects of melatonin.”
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