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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon-Alpha
supplement:
Lycopene
Research Papers that Mention the Interaction
“These results demonstrate that lycopene has a potent anti-angiogenic effect and that these effect may be associated with its up-regulation of IL-12 and IFN-γ.”
Anti-angiogenic effects of lycopene through immunomodualtion of cytokine secretion in human peripheral blood mononuclear cells.“ Lycopene induced a dose-dependent increase in IL1β, and TNFα production and a decrease in IL-2, IL-10 and IFNγ secretion, whereas that of IL-6 and IL-1ra was not affected.”
“By the methods of immunoprecipitation and immunoblotting, we also found that lycopene inhibited the subsequent formation of the complex of TLR4 with its adaptors including myeloid differentiation primary-response protein 88 and TIR domain-containing adaptor-inducing IFN-β.”
Lycopene suppresses proinflammatory response in lipopolysaccharide-stimulated macrophages by inhibiting ROS-induced trafficking of TLR4 to lipid raft-like domains.
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