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Last Updated: 2 years ago

Possible Interaction: Interferon-Alpha and Kaempferol

Research Papers that Mention the Interaction

Cell experiments indicated that the pathogenesis of psoriasis was significantly related to the increase in IFN-γ , which promoted the transcriptional expression and exosome secretion of HSP90 in HaCaT cells; conversely, luteolin inhibited those and alleviated the promotion of IFN-γ.
International immunopharmacology  •  2020  |  View Paper
Treatment with luteolin also improved IFN-γ mRNA expression in the colon.
BioFactors  •  2013  |  View Paper
We conducted cell-based screening for IFN signaling enhancer and discovered that luteolin , a natural flavonoid, sensitized the antiproliferative effect of IFN-α in hepatoma HepG2 cells and cervical carcinoma HeLa cells.
Cellular signalling  •  2014  |  View Paper
In the majority of cases, luteolin , when combined with IFN-β , had additive effects in modulating cell proliferation, IL-1β, TNF-α, MMP-9 and TIMP-1.
Journal of Neuroinflammation  •  2009  |  View Paper
Finally, a significant (p < 0.05) decrease in IFN-γ , TNF-α, IL-1α and IL-18 levels was observed most notably in groups that received high doses of luteolin (50 and 100 mg/kg).
Pharmacological reports : PR  •  2019  |  View Paper
Moreover, the PT leaf extract and luteolin potently down-regulated the expression of tumor necrosis factor (TNF)-α, Interleukin (IL)-1β, IL-6, NO and iNOS and the production of gamma interferon ( IFN-γ ), which are directly involved in controlling the NF-κB signaling pathway.
PloS one  •  2015  |  View Paper
Daidzein, genistein, luteolin and apigenin, the main flavonoids present in diffusates of elicited cotyledons, suppressed the NO production by LPS + IFNγ activated macrophages in a concentration-dependent manner, with IC50 values of 81.4 μM, 34.5 μM, 38.6 μM and 10.4 μM respectively.
BMC Biochemistry  •  2003  |  View Paper
In conclusion, both apigenin and luteolin significantly suppressed lung cancer with KRAS mutant proliferation, and down-regulated the IFN-γ induced PD-L1 expression.
Cancer letters  •  2021  |  View Paper
Kaempferol-treatment could induce higher levels of IL-1β, IL-4, IL-6, TNF-α and IFN-γ in the serum at 3 dpi which were then declined to normal levels at 5 dpi.
BMC Veterinary Research  •  2021  |  View Paper