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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Interferon-Alpha and Kaempferol

Research Papers that Mention the Interaction

We conducted cell-based screening for IFN signaling enhancer and discovered that luteolin , a natural flavonoid, sensitized the antiproliferative effect of IFN-α in hepatoma HepG2 cells and cervical carcinoma HeLa cells.
Cellular signalling  •  2014  |  View Paper
In the majority of cases, luteolin , when combined with IFN-β , had additive effects in modulating cell proliferation, IL-1β, TNF-α, MMP-9 and TIMP-1.
Journal of Neuroinflammation  •  2009  |  View Paper
Finally, a significant (p < 0.05) decrease in IFN-γ , TNF-α, IL-1α and IL-18 levels was observed most notably in groups that received high doses of luteolin (50 and 100 mg/kg).
Pharmacological reports : PR  •  2019  |  View Paper
Treatment with luteolin also improved IFN-γ mRNA expression in the colon.
BioFactors  •  2013  |  View Paper
In contrast, luteolin significantly increased IL-10 and IFN-γ protein levels, as well as IL-10 and TGF-β1 mRNA expression in the lung.
European journal of pharmacology  •  2018  |  View Paper
Moreover, the PT leaf extract and luteolin potently down-regulated the expression of tumor necrosis factor (TNF)-α, Interleukin (IL)-1β, IL-6, NO and iNOS and the production of gamma interferon ( IFN-γ ), which are directly involved in controlling the NF-κB signaling pathway.
PloS one  •  2015  |  View Paper