Possible Interaction: Interferon-Alpha and Kaempferol

“Cell experiments indicated that the pathogenesis of psoriasis was significantly related to the increase in IFN-γ , which promoted the transcriptional expression and exosome secretion of HSP90 in HaCaT cells; conversely, luteolin inhibited those and alleviated the promotion of IFN-γ.”

“Treatment with luteolin also improved IFN-γ mRNA expression in the colon.”

“We conducted cell-based screening for IFN signaling enhancer and discovered that luteolin , a natural flavonoid, sensitized the antiproliferative effect of IFN-α in hepatoma HepG2 cells and cervical carcinoma HeLa cells.”

“In the majority of cases, luteolin , when combined with IFN-β , had additive effects in modulating cell proliferation, IL-1β, TNF-α, MMP-9 and TIMP-1.”

“Finally, a significant (p < 0.05) decrease in IFN-γ , TNF-α, IL-1α and IL-18 levels was observed most notably in groups that received high doses of luteolin (50 and 100 mg/kg).”

“Moreover, the PT leaf extract and luteolin potently down-regulated the expression of tumor necrosis factor (TNF)-α, Interleukin (IL)-1β, IL-6, NO and iNOS and the production of gamma interferon ( IFN-γ ), which are directly involved in controlling the NF-κB signaling pathway.”

“Daidzein, genistein, luteolin and apigenin, the main flavonoids present in diffusates of elicited cotyledons, suppressed the NO production by LPS + IFNγ activated macrophages in a concentration-dependent manner, with IC50 values of 81.4 μM, 34.5 μM, 38.6 μM and 10.4 μM respectively.”

“In conclusion, both apigenin and luteolin significantly suppressed lung cancer with KRAS mutant proliferation, and down-regulated the IFN-γ induced PD-L1 expression.”

“ Kaempferol-treatment could induce higher levels of IL-1β, IL-4, IL-6, TNF-α and IFN-γ in the serum at 3 dpi which were then declined to normal levels at 5 dpi.”