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Last Updated: 3 years ago

Possible Interaction: Interferon-Alpha and Iron, Dietary

Research Papers that Mention the Interaction

Iron loading inhibited hepcidin mRNA expression induced by IFN‐γ and M. avium, and iron chelation increased hepcidin mRNA expression.
Journal of leukocyte biology  •  2007  |  View Paper
Collectively, IFN-γ significantly inhibits pathogen-associated intracellular iron sequestration in macrophages and consequently retards the growth of intracellular bacterial pathogens by decreasing iron availability.
We hypothesize that IFN-γ decreases iron availability to intracellular pathogens consequently limiting replication in these cells.
PloS one  •  2020  |  View Paper
Gamma interferon IFN-γ ) reduced MDM Fe uptake from each chelate by ∼50% and augmented the M. tuberculosis-induced decrease in MDM Fe uptake from exogenous TF, but not from LF or citrate.
IFN-γ minimally decreased intracellular M. tuberculosis Fe acquisition from exogenous Fe-TF but significantly increased Fe uptake from LF and citrate.
Infection and Immunity  •  2004  |  View Paper
Moreover, IFN-γ induced the association of Fer and Stat3 and the newly formed complex was most stable at the down-regulated states of the two proteins.
Oncogene  •  2002  |  View Paper
The action cross section for induction of hprt-deficient mutants by energetic Fe ions is more than 10-fold lower for lymphoblastoid cells than for fibroblasts.
Advances in space research : the official journal of the Committee on Space Research  •  1994  |  View Paper
Using the human monocytic cell line, THP-1, we found that heme, Zn-mesoporphyrin, Zn-deuteroporphyrin, Co-protoporphyrin, and iron reduced the efficiency of the IFN-γ signal.
Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine  •  1993  |  View Paper
As the activity of IFN‐γ is modulated by iron and since a sufficient availability of iron is essential for the growth of pathogens, we investigated the regulatory effects of IFN‐γ on iron homeostasis and immune function in murine macrophages infected with Salmonella typhimurium.
European journal of immunology  •  2008  |  View Paper
Iron also down‐regulated NO production and increased the viability of L929 fibrosarcoma cells stimulated with IFN‐γ + LPS in the absence of macrophages.
Clinical and experimental immunology  •  2004  |  View Paper
We found that macrophage‐activating cytokines, including TNF‐α, IFN‐γ , IL‐1α, and GM‐CSF, when added prior to M. avium, increased the transport of iron into the phagosome.
Journal of leukocyte biology  •  2001  |  View Paper