Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 2 years ago

Possible Interaction: Interferon-Alpha and Hesperidin

Research Papers that Mention the Interaction

Furthermore, hesperidin treatment significantly (p < .05) reduced serum interferon gamma ( IFN-γ ) and interleukin-4 (IL-4) levels in arthritic rat.
Immunopharmacology and immunotoxicology  •  2020  |  View Paper
Furthermore, hepatic oxidative stress and the production of proinflammatory cytokines including TNF-α and IFN-γ were decreased by HDN pretreatment.
International immunopharmacology  •  2014  |  View Paper
Our findings indicate that IFN-γ induced expression of PD-L1 protein in HN6 and HN15 via phosphorylation of STAT1 and STAT3 and that hesperidin significantly reduced that induction through suppression of phosphorylated STAT1 and STAT3 in both cell lines.
The aim of this study was to investigate whether suppression of IFN-γ induced PD-L1 expression in two oral cancer cell lines, HN6 and HN15, by hesperidin effectively decreased cell proliferation and migration.
Molecules  •  2021  |  View Paper