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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon-Alpha
supplement:
Glucose
Research Papers that Mention the Interaction
“In this study, by using live … biochemical approaches, we demonstrate that IFN-γ plus high glucose augment endothelial connexin43 hemichannel activity, resulting in the increase of ATP release, ATP-mediated Ca2+ … of nitric oxide and superoxide anion, as well as impaired insulin-mediated uptake and intercellular diffusion of glucose ….”
Interferon-γ and high glucose-induced opening of Cx43 hemichannels causes endothelial cell dysfunction and damage.“The Ra of glucose was higher at the end of the recombinant human IFN alpha treatment day than in the control experiment (12.83 +/- 1.08 vs. 9.34 +/- 0.46 mumol/kg.min; P < 0.03).”
“These data demonstrate that in LY, the antiproliferative effects of IFNα are associated with a reduction in glucose and glutamine metabolisms.”
Changes in Glucose and Glutamine Lymphocyte Metabolisms Induced by Type I Interferon α“Maximal impairment was seen when glucose was added to the IFN-treated RK-13 cells early during the development of antiviral activity.”
“Therefore, glucose restriction reduces IFNγ production in iNKT cells by interfering with TCR signaling.”
Challenges of iNKT cell-based antitumor immunotherapies“However, when glucose was used, the initiation of recombinant interferon-alpha expression was delayed compared with that when glycerol was used.”
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