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Last Updated: 3 years ago

Possible Interaction: Interferon-Alpha and Epigallocatechin Gallate

Research Papers that Mention the Interaction

The mRNA and protein levels of IFN-γ –induced PD-L1 were reduced 40–80% after pretreatment with EGCG and green tea extract (GTE) in A549 cells, via inhibition of JAK2/STAT1 signaling.
Molecules  •  2018  |  View Paper
Interestingly, EGCG promoted apoptosis of CD4(+) T cells treated with IFN-γ.
Our findings suggest a novel role of EGCG in regulating IFN-γ signaling and controlling inflammation.
EGCG enhanced IFN-γ-induced signal transducer and activator of transcription 1 (STAT1) activation in …-cell line of Hut 78 cells, while it inhibited the classical pathway of IFN-γ signaling including activating phosphorylations of Janus kinase (JAK) 1, JAK2 …-inflammatory chemokine (C-X-C motif) ligand 9 (CXCL9).
International immunopharmacology  •  2014  |  View Paper
The upregulation of the levels of macrophage gamma interferon IFN-γ ) mRNA by EGCg was also demonstrated.
Infection and Immunity  •  2001  |  View Paper
In the current study, we showed that EGCG treatment significantly increased the poly I:C-induced expression of Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I, and IFN-λ1 in JFH-1-Huh7 cells.
World journal of gastroenterology  •  2017  |  View Paper
As a consequence, adhesion of human T cells to melanocytes induced by IFN-γ was effectively suppressed by EGCG.
Biological & pharmaceutical bulletin  •  2015  |  View Paper
IFN-γ production was also significantly suppressed by EGCG in vitro.
BMC Complementary and Alternative Medicine  •  2014  |  View Paper
EGCG also inhibited IL6 secretion and IFN- β mRNA synthesis in BEAS-2B cells, which harbors intact endogenous RIG-I signaling pathway.
PloS one  •  2010  |  View Paper
We measured liver tissue and found that the EGCG gavage treatment significantly inhibited the pro-inflammatory factors (TNF-α, IL-1β, IL-6, MCP-1, MIP-2, IFN-γ ) and oxidation indicators (MPO, NO, ALT, and AST) levels increase.
Frontiers in Immunology  •  2021  |  View Paper
As a result, EGCG significantly decreased SEA-induced expression and production of interferon gamma ( IFN-γ).
Molecules  •  2020  |  View Paper
At 20μM dilution, both CHX and EGCG significantly increased the secretion of IL-1β, IL-10, IL-12, KC, MIP-1α, IFN-γ and IL-6 (p<0.05).
Dental materials : official publication of the Academy of Dental Materials  •  2018  |  View Paper
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