Possible Interaction: Interferon-Alpha and Epigallocatechin Gallate

“The mRNA and protein levels of IFN-γ –induced PD-L1 were reduced 40–80% after pretreatment with EGCG and green tea extract (GTE) in A549 cells, via inhibition of JAK2/STAT1 signaling.”

“Interestingly, EGCG promoted apoptosis of CD4(+) T cells treated with IFN-γ.”

“Our findings suggest a novel role of EGCG in regulating IFN-γ signaling and controlling inflammation.”

“… EGCG enhanced IFN-γ-induced signal transducer and activator of transcription 1 (STAT1) activation in …-cell line of Hut 78 cells, while it inhibited the classical pathway of IFN-γ signaling including activating phosphorylations of Janus kinase (JAK) 1, JAK2 …-inflammatory chemokine (C-X-C motif) ligand 9 (CXCL9).”

“The upregulation of the levels of macrophage gamma interferon IFN-γ ) mRNA by EGCg was also demonstrated.”

“In the current study, we showed that EGCG treatment significantly increased the poly I:C-induced expression of Toll-like receptor 3 (TLR3), retinoic acid-inducible gene I, and IFN-λ1 in JFH-1-Huh7 cells.”

“As a consequence, adhesion of human T cells to melanocytes induced by IFN-γ was effectively suppressed by EGCG.”

“ IFN-γ production was also significantly suppressed by EGCG in vitro.”

“ EGCG also inhibited IL6 secretion and IFN- β mRNA synthesis in BEAS-2B cells, which harbors intact endogenous RIG-I signaling pathway.”

“We measured liver tissue and found that the EGCG gavage treatment significantly inhibited the pro-inflammatory factors (TNF-α, IL-1β, IL-6, MCP-1, MIP-2, IFN-γ ) and oxidation indicators (MPO, NO, ALT, and AST) levels increase.”

“As a result, EGCG significantly decreased SEA-induced expression and production of interferon gamma ( IFN-γ).”

“At 20μM dilution, both CHX and EGCG significantly increased the secretion of IL-1β, IL-10, IL-12, KC, MIP-1α, IFN-γ and IL-6 (p<0.05).”