Possible Interaction: Interferon-Alpha and Dehydroepiandrosterone

“Taken together, these results showed that DHEA inhibited the proliferation and promoted the apoptosis of ovarian granulosa cells through downregulating the expression of IFN‐γ which could be restored by flutamide, and IFN‐γ may serve as a potential inflammatory biomarker for PCOS detection.”

“The results also revealed that IFN‐γ promoted the proliferation but inhibited the apoptosis of KGN cells, which was suppressed by DHEA via activating the downstream PI3K/AKT signaling pathway.”

“Using the ovarian granulosa cells (KGN), we demonstrated that DHEA downregulated the expression and secretion of IFN‐γ in dose‐ and time‐dependent manners, which could be restored to some extent by treating with flutamide.”

“ DHEA reverses B. abortus downmodulation of the MHC-I and -II expression induced by IFN-γ.”

“Importantly, we observed that DHEA enhanced the antigen-specific T-cell proliferation and IFN-γ production induced by M. tuberculosis-stimulated DC.”

“In contrast, addition of DHEA to cultures of cells from HHCs resulted in increased IFN‐γ levels.”

“Results In PBMCs from subjects exhibiting methacholine airway hyperresponsiveness (AHR), DHEA significantly suppressed IL-10, IL-5, and IFN-γ production in a dose-dependent manner (all p<0.001) and tended to increase the IFN-γ/IL-5 ratio (p=0.087).”

“Furthermore, DHEA significantly increased the Th1 type cytokine (IL-2 and IFN-α ) and decreased the Th2 type cytokine (IL-4 and IL-10) levels in LPS-induced mice or in primary cultured spleen T lymphocytes.”

“Here we showed that low dose DHEA inhibited proliferation of spleen cells and IFN-у production.”

“The uninfected mice supplemented with 0.06% DHEA showed a significant (P < 0.05) increase in interleukin-2 (IL-2) and γ-interferon ( IFN-γ ) production, and hepatic vitamin E levels.”