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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon-Alpha
supplement:
Cocaine
Research Papers that Mention the Interaction
“Although we found that cocaine (45 mg/kg, i.p./day x 5) significantly increased IL-6 and TNF-α expression, it resulted in a decrease in IFN-γ expression.”
IL-6 knockout mice are protected from cocaine-induced kindling behaviors; possible involvement of JAK2/STAT3 and PACAP signalings.“Oncomice thymocytes cultured in the presence of Con A and cocaine showed a diminished release of sIL-2R and a lower secretion of IFN-γ , a phenomenon not observed in FVB thymocytes.”
“Our findings suggest that the immunomodulatory effects of cocaine may be due to the up‐regulation of the production of IL‐2 and IFN‐γ by CD8+ T cells with a type 0 cytokine profile.”
“The … that cocaine , administered during the in vivo virus‐induced differentiation of T cells, caused an increase … the frequencies of CD8+ T cells singly and co‐expressing IL‐2 and IFN‐γ and the levels of these cytokines in virus‐restimulated … culture supernatants, compared with those of untreated controls.”
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