Possible Interaction: Interferon-Alpha and Catechin

“In aged animals, poly I C induced exaggerated IL-6, IL-1β and IFN-I in the plasma and similar exaggerated brain cytokine responses.”

“Gene expression of IFNβ, IFNλ2 and IFN-stimulated genes (ISGs) were upregulated in response to poly I: C and a further increase in gene expression was observed following IC87114 treatment.”

“As in B16 cells, poly I C plus IFN-γ synergism reduced UM-SCC1 and UM-SCC38 growth, and no more than 24 h was needed for significant growth reduction.”

“Poly I C induced IFN-β , MDA5, and CXCL10 expression in a concentration- and time-dependent manner.”

“Addition of poly I C significantly enhanced the expression and secretion of IFNγ , IDO and HLA-G. Knockdown of TLR3 using siRNA decreased the poly I:C-induced expression of these three molecules.”

“HBV genotypes D and C are associated with a lower rate of favorable response to interferon alpha therapy than genotypes A and B, respectively.”

“In contrast long (HMW) poly I C preferably elicit higher IFNβ expression in non-myeloid (fibroblast) cell.”

“The combination of Pam3CSK4 and poly I C synergistically upregulated IFN-β , IFN-γ, IL-12, IL-4, and IL-13 transcripts and cross-inhibited IL-1β, IL-10, and iNOS transcripts in the chicken peripheral blood mononuclear cells (PBMCs) as analyzed by quantitative real-time PCR.”

“Compared with A and B groups, the serum levels of IFN-γ in C , D, and E groups were significantly increased (F = 63.525, P < 0.01).”

“Poly I C induced IFN-γ expression by NK cells in the MLN, which was mediated through type I IFNs and IL-12p40 from antigen presenting cells and consequent activation of STAT1 and STAT4 in NK cells.”