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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon-Alpha
supplement:
Cannabidiol
Research Papers that Mention the Interaction
“Analysis of the jejunum and ileum showed that CBD treatment reduced the levels of CCL2, CCL3, CCL5, TNF-α, and IFN-γ.”
Cannabidiol Enhances Intestinal Cannabinoid Receptor Type 2 Receptor Expression and Activation Increasing Regulatory T Cells and Reduces Murine Acute Graft-versus-Host Disease without Interfering with the Graft-versus-Leukemia Response“ CBD at 4 µg/mL significantly reduced production of IFN-γ and TNF-α (P < .05).”
“THC produced little to no change in serum cytokines, whereas CBD decreased IL-1β, IL-10, and IFN-γ and increased IL-6.”
“In addition, our data demonstrated that therapeutic efficacy of CBD treatment is due to reduction of pro-inflammatory cytokines, like IFN-γ and IL-17 together with an up-regulation of PPARγ.”
“THC or CBD suppressed or enhanced IFN‐γ and IL‐2 production by mouse splenocytes under optimal or suboptimal stimulation, respectively.”
“ CBD treatment also resulted in the significant reduction of plasma levels of the pro-inflammatory cytokines, IFN-γ and TNF-α.”
“CBD attenuated clinical disease, and we found that CBD suppressed IFN-γ producing CD8 + T cells in the spleen at day 10.”
CBD Suppression of EAE Is Correlated with Early Inhibition of Splenic IFN-γ + CD8+ T Cells and Modest Inhibition of Neuroinflammation
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