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Discover Supplement-Drug Interactions

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Last Updated: 4 months ago

Possible Interaction: Interferon-Alpha and Arginine



Research Papers that Mention the Interaction

L-Arg depletion reduced the expression of NK-92 activating receptors, NKp46 and NKp30, the expression of NK ζ chain and the NK-92 intracellular production of IFN-γ.
Cellular immunology  •  2012  |  View Paper
Furthermore, we found that IFN-γ promoted arginine depletion, activated the general control nonderepressible-2 kinase (GCN2) signalling pathway and resulted in an increase in autophagic flux and the amount of autophagy in BMECs.
Cell Death Discovery  •  2016  |  View Paper
The results indicate that arginine addition could alleviate the malignant transformation of mammary epithelial cells induced by IFN-γ , including reducing cell proliferation, cell migration and colony formation, through the NF-κB-GCN2/eIF2α pathway.
Experimental cell research  •  2018  |  View Paper
We found L-arginine supplementation enhanced Th1 immune response by increasing IFN-γ production.
Front. Immunol.  •  2018  |  View Paper
Furthermore, mechanistic analysis confirmed that IFN-γ mediated autophagy by depleting arginine and inhibiting the general control nonderepressible-2 kinase (GCN2)/eukaryotic initiation factor 2α (eIF2α) signaling pathway in BMECs.
Molecules and cells  •  2016  |  View Paper
The levels of pro-inflammatory cytokines, IFN-γ and TNF-α, in splenocyte cultures were also increased by L-Arg treatment.
The Tohoku journal of experimental medicine  •  2015  |  View Paper
Animals supplemented with parenteral arginine had significantly decreased productions of concanavalin (Con) A- and lipopolysaccharide (LPS)-stimulated TNF-α in PBLs and splenocytes, spontaneous IL-6 and LPS-stimulated IFN-γ in PBLs, and LPS-stimulated IL-6 in splenocytes.
In addition, low-dose arginine significantly increased production of spontaneous IFN-γ in PBLs and splenocytes.
JPEN. Journal of parenteral and enteral nutrition  •  2012  |  View Paper