Possible Interaction: Interferon-Alpha and Arginine

“ L-Arg depletion reduced the expression of NK-92 activating receptors, NKp46 and NKp30, the expression of NK ζ chain and the NK-92 intracellular production of IFN-γ.”

“In GVHD patients, increasing arginine concentration resulted in down-regulation of IFNγ and TNFα mRNA expression, whereas IL10 was up-regulated especially at physiological plasma levels (between 0 and 100 μM).”

“ IFN‐γ induced a weak increase in IL‐17 R mRNA abundance, and incubation with IFN‐γ for 24 h enhanced [125I]‐labelled IL‐17‐binding by 2·4‐fold.”

“ IFN-γ increased the activity of arginase II and reduced the level of arginine in cells, while the addition of arginine inhibited the expression of TLR4 and CCL5.”

“These data reveal that increased IFN-γ reduces arginine levels and activates TLR4-CCL5 signaling, leading to enhanced susceptibility of BMECs to S. aureus.”

“Furthermore, mechanistic analysis confirmed that IFN-γ mediated autophagy by depleting arginine and inhibiting the general control nonderepressible-2 kinase (GCN2)/eukaryotic initiation factor 2α (eIF2α) signaling pathway in BMECs.”

“The levels of pro-inflammatory cytokines, IFN-γ and TNF-α, in splenocyte cultures were also increased by L-Arg treatment.”

“In addition, low-dose arginine significantly increased production of spontaneous IFN-γ in PBLs and splenocytes.”

“The results indicate that in certain RCC cell lines, IFNγ modulates L-arginine metabolism by shifting from arginase to iNOS activity, thereby developing a potent inhibitory mechanism to encumber tumor cell proliferation and survival.”

“ Interferon-alpha was found to enhance arginine vasopressin release from both hypothalamus and amygdala, as was dibutyryl cyclic GMP.”

“Taken with previous reports that interferon-alpha … hormone release, our results suggest that arginine … interferon-alpha may also contribute to the activation of the hypothalamic-pituitary axis, while the ability of transforming growth … diminish the arginine vasopressin released by acetylcholine could mediate some of this cytokine's central effects.”

“We conclude that induction of inorganic nitrogen oxide synthesis from l‐arginine by the synergistic combination of IFNγ , TNFα, and LPS accounts for most of the biologic activity of CM, and that IFNγ is the major priming factor.”