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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Interferon-Alpha and Arachidonic Acid

Research Papers that Mention the Interaction

Further mechanistic analysis revealed that AA interfered with the transcriptional function of the IFNγ signalling pathway by reducing phosphorylation of signal transducer and activator of transcription (STAT1) on tyrosine 701.
Using human acute monocytic leukaemic THP-1 cells and human primary monocytes, this study examined the ability of arachidonic acid AA ) to modulate the activity of the IFNγ signalling cascade and its downstream effector indoleamine 2,3-dioxygenase (IDO).
Prostaglandins, leukotrienes, and essential fatty acids  •  2012  |  View Paper
IFN-α caused a dose-dependent release of AA from phospholipids and metabolism of a modest fraction of leukotriene B4 (LTB4) and 5-hydroxyeicosatetraenoic acid (5-HETE) at doses reaching a maximum of 100 IU/ml.
Inflammation  •  2004  |  View Paper
Arachidonic acid metabolites seem to play an important role in modulating the post-receptorial activity of interferon-alpha.
Journal of hepatology  •  1993  |  View Paper