Possible Interaction: Interferon-Alpha and Apigenin

“Furthermore, we demonstrated that apigenin could enhance the anticancer activity of IFNγ in a HeLa cervical AC cell line by targeting cyclin-dependent kinase 1.”

“Daidzein, genistein, luteolin and apigenin , the main flavonoids present in diffusates of elicited cotyledons, suppressed the NO production by LPS + IFNγ activated macrophages in a concentration-dependent manner, with IC50 values of 81.4 μM, 34.5 μM, 38.6 μM and 10.4 μM respectively.”

“In conclusion, both apigenin and luteolin significantly suppressed lung cancer with KRAS mutant proliferation, and down-regulated the IFN-γ induced PD-L1 expression.”

“Conclusion: Apigenin regulates Th1/Th2 balance via suppression in expressions of Th2 response (IgE, histamine, ILs, GATA3, STAT6, SOCS1, and NF-κB) and activation of Th1 response ( IFN-γ and T-bet) to exert its anti-allergic potential in a murine model of OVA-induced AR.”

“This study demonstrated that Apigenin treatment significantly suppressed IAV‐induced upregulation of retinoic acid‐inducible gene‐I (RIG‐I) expression, as well as the production of proinflammatory cytokines and interferons ( IFN‐β and IFN‐λ1).”

“ Apigenin also sensitized the inhibitory effect of IFN-α on viability of cervical carcinoma HeLa cells.”

“Conclusion These results suggest that apigenin potentiates the inhibitory effect of IFN-α on cancer cell viability by activating JAK/STAT signaling pathway through inhibition of 26S proteasome-mediated IFNAR1 degradation.”