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Last Updated: 3 years ago

Possible Interaction: Interferon-Alpha and Apigenin



Research Papers that Mention the Interaction

Furthermore, we demonstrated that apigenin could enhance the anticancer activity of IFNγ in a HeLa cervical AC cell line by targeting cyclin-dependent kinase 1.
Oncotarget  •  2017  |  View Paper
Daidzein, genistein, luteolin and apigenin , the main flavonoids present in diffusates of elicited cotyledons, suppressed the NO production by LPS + IFNγ activated macrophages in a concentration-dependent manner, with IC50 values of 81.4 μM, 34.5 μM, 38.6 μM and 10.4 μM respectively.
BMC Biochemistry  •  2003  |  View Paper
In conclusion, both apigenin and luteolin significantly suppressed lung cancer with KRAS mutant proliferation, and down-regulated the IFN-γ induced PD-L1 expression.
Cancer letters  •  2021  |  View Paper
Conclusion: Apigenin regulates Th1/Th2 balance via suppression in expressions of Th2 response (IgE, histamine, ILs, GATA3, STAT6, SOCS1, and NF-κB) and activation of Th1 response ( IFN-γ and T-bet) to exert its anti-allergic potential in a murine model of OVA-induced AR.
Dose-response : a publication of International Hormesis Society  •  2020  |  View Paper
This study demonstrated that Apigenin treatment significantly suppressed IAV‐induced upregulation of retinoic acid‐inducible gene‐I (RIG‐I) expression, as well as the production of proinflammatory cytokines and interferons ( IFN‐β and IFN‐λ1).
Journal of medical virology  •  2020  |  View Paper
Apigenin also sensitized the inhibitory effect of IFN-α on viability of cervical carcinoma HeLa cells.
Conclusion These results suggest that apigenin potentiates the inhibitory effect of IFN-α on cancer cell viability by activating JAK/STAT signaling pathway through inhibition of 26S proteasome-mediated IFNAR1 degradation.
Food & nutrition research  •  2016  |  View Paper