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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Interferon-Alpha
supplement:
Antioxidants
Research Papers that Mention the Interaction
“Importantly treatment with an antioxidant led to increased IFN-γ and reduced IL-10 production in human chronic Hep-B/C samples suggesting overall a proximal regulatory role for iCa2+ influx, ROS, and IL-10 in determining the effector/ suppressive axis of CD8+ T cells.”
iCa2+ Flux, ROS and IL-10 Determines Cytotoxic, and Suppressor T Cell Functions in Chronic Human Viral Infections“The combination of rectal and topical dosage forms of IFN-α2b with antioxidants was more effective than monotherapy with the rectal suppositories in preventing repeated hospitalization for ARI.”
“These results indicate that NO and antioxidants may attenuate vascular inflammation by antagonizing the effects of intracellular reactive oxygen species generation by IFN-γ , which is necessary for MHC-II gene transcription.”
“Furthermore, treatment of NKT cells with antioxidants led to reduced frequencies of IFN-γ– and IL-17–expressing cells, indicating that ROS play a role in regulating the inflammatory function of NKT cells.”
Reactive Oxygen Species Regulate the Inflammatory Function of NKT Cells through Promyelocytic Leukemia Zinc Finger
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