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Last Updated: 2 months ago

Possible Interaction: Interferon Alfa-2A and Tretinoin

Research Papers that Mention the Interaction

When animals bearing human HNSCC tumor cells were treated systemically with a combination of RA and IFN-alpha A/D at doses that were ineffective when used alone, dramatic decreases in both tumor growth and tumor angiogenesis were seen.
Cancer research  •  1998  |  View Paper
Retinoids combined with interferon alpha-2a (IFN alpha) or 1,25-dihydroxyvitamin D3 [1,25(OH)2D3] have shown marked synergistic inhibitory effects on angiogenesis induced by tumor cell lines harboring DNA of oncogenic human papillomaviruses (HPV) type 16 or 18.
The antiangiogenic effect of retinoids could be significantly enhanced by combination with IFN alpha or 1,25(OH)2D3.
Cancer letters  •  1995  |  View Paper
The effects of these retinoids on cell growth and apoptosis were enhanced by IFN.
The Journal of urology  •  2005  |  View Paper
We report two APL cases with platelet counts >1000 × 109/l during ATRA therapy who were treated with recombinant interferon alpha.
British journal of haematology  •  1996  |  View Paper
The combination of 10 nM RA and IFN-alpha A/D at concentrations of 120 units/ml and higher induces differentiation into cells having many monocytic characteristics such as monocyte-like morphology, ability of superoxide anion production, antibody-dependent cellular cytotoxicity, and nonspecific esterase activity.
Journal of interferon research  •  1987  |  View Paper
We now report that a combination of recombinant interferon alpha (Intron; Schering) and retinoic acid is synergistically cytostatic for HL-60 cells.
Experimental hematology  •  1987  |  View Paper