Possible Interaction: Insulin and Vitamin K

“ Vitamin K2 (VK2) has a beneficial role in improving insulin sensitivity and glucose metabolism.”

“Supplementation of vitamin K may reduce the risk of diabetes mellitus and improve insulin sensitivity.”

“Moreover, several human studies reported the beneficial role of vitamin K supplementation in improving insulin sensitivity and glucose tolerance, preventing insulin resistance, and reducing the risk of type 2 diabetes (T2 D).”

“NH4+ and menadione , agents that promote a more oxidized state in islet NADP, did not affect islet ATP content or the rates of [U-14C]4-methyl-2-oxopentanoate oxidation or amination, but markedly inhibited islet 45Ca uptake and insulin release.”

“ Menadione inhibits the effect of pyruvate on insulin release , without altering its rate of oxidation.”

“Since, in the presence of glucose 11.1 mM, menadione 10 micrometer also severely decreases glucose-stimulated45 calcium net uptake and subsequent insulin release , it is concluded that the availability of reduced pyridine nucleotides may play an essential role in the secretory sequence by coupling metabolic to cationic events.”

“However, epidemiological studies find positive associations between vitamin K intake and insulin sensitivity.”

“Results Menaquinone‐7 supplementation, when compared to placebo, significantly decreased serum fasting insulin (p = .002), homeostasis model of assessment insulin resistance (p = .002), and homeostasis model of assessment β‐cell function (p = .02) in addition to a significant increase in quantitative insulin sensitivity check index (p = .001).”