Possible Interaction: Insulin and Vitamin E

“Conclusions: Combined administration of Vitamin E and C lowered inflammation and improved insulin action through a rise in non-oxidative glucose metabolism.”

“Objective: Vitamin E and C given separately improve insulin sensitivity due to an inhibitory effect on oxidative stress and inflammation, however their combined effect on glucose control and inflammation is unknown.”

“ Vitamin E is an antioxidant that has been demonstrated to improve insulin action.”

“It is supposed that treatment with antioxidant alpha-tocopherol vitamin E ) could not only decrease free radical production, but also ameliorate insulin action.”

“our results demonstrate that higher doses of vitamin E may further deteriorate insulin action and fibrinolysis in obese Type 2 diabetic patients.”

“Glycosylated haemoglobin and insulin dose were also similar between the two groups; however patients receiving Vit E under the age of 15 years required significantly more insulin than NA-treated patients one year after diagnosis (P < 0.04).”

“ Vitamin E improves insulin action in healthy, elderly, and non-insulin-dependent diabetic subjects.”

“Our meta-analysis indicated that the co-supplementation with magnesium and vitamin E resulted in a significant decrease in FPG, Insulin , HOMA-IR, TG, TC, and LDL-C in comparison with placebo.”

“Distance and angle calculation results illustrated that vitamin E changes the B-chain conformation and it causes the formation of wide-open/active form of insulin.”

“… vitamin E … insulin (-1.0±3.5 vs. +2.7±6.6 µIU/mL, P=0.004), homeostasis model of assessment-estimated insulin resistance (-0.2±….004) and a significant increase in quantitative insulin sensitivity check index (+0.006±0.02 vs. -0.01±0.04, P=0.008).”

“In the general population, vitamin E supplementation has been suggested to improve both insulin sensitivity and secretion.”

“Far- and near-UV circular dichroism studies showed that vitamin E can significantly change the secondary and tertiary structures of human insulin via an increase in the content of α-helix structure.”