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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“2) The plasma concentration of insulin, when tested in the vitamin C infusion system, followed a bimodal curve--a finding to suggest that vitamin C may stimulate the insulin mechanism in 2 distinct ways.”
Diabetes mellitus is controlled by vitamin C treatment.“The absence of insulin also significantly reduced ascorbic acid uptake.”
“The cellular uptake of vitamin C (ascorbic acid, ASC) is promoted by insulin and inhibited by hyperglycemia.”
“It is concluded that insulin influences vitamin C metabolism in the peripheral tissues in man, and that the response is abnormal in many diabetic subjects.”
“Treatment with vitamin C reversed the changes in the MDA, cortisol and plasma insulin levels.”
Vitamin C Prevents Sleep Deprivation-induced Elevation in Cortisol and Lipid Peroxidation in the Rat Plasma.“Insulin induced apelin mRNA expression, but VC inhibited its expression in cocultures under insulin treatment.”
“In addition, VC (200 microM) induced Cdkn1a and Casp8, partially inhibited Irs3, and together with insulin drastically reduced Gpdh (listed as Gpd1 in the MGI database) gene expressions.”
“Immunohistochemical findings on pancreatic islets showed increased staining intensity for both insulin and glucagon when vitamin C was supplemented.”
“However, in the insulin plus ascorbic acid treatment group, reduced form and the ratio of reduced/total ascorbic acid were significantly increased as compared with diabetic control.”
“ConclusionsThe results indicate that enhanced NO release by vitamin C affects postprandial blood glucose and plasma insulin levels and the reduced glucose tolerance is mainly due to impaired insulin release.”
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