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“Supplementation with folic acid and vitamin B12 suppressed the nicotine induced changes in HbA1c, insulin , TNF-α, IL-6, generation of reactive oxygen species, and attenuated the changes in markers of oxidative stress.”
“In some experiments the addition of insulin (0.5 unit/ml) and vitamin B12 (0.5 µg/ml) has further enhanced the secondary response in this serum-free medium.”