Possible Interaction: Insulin and Vanadium

“The observations that the glucose-lowering effect of vanadium depends on the presence of endogenous insulin whereas metabolic homeostasis in control animals appears not to be affected, suggest that vanadium does not act completely independently in vivo, but augments tissue sensitivity to low levels of plasma insulin.”

“Addition of vanadium in three different doses to the diet over 100-day experiment reduced body weight gain and the levels of glucose, insulin , leptin, and triglycerides.”

“We can conclude that concomitant administration of both vanadium and insulin in T1DM decreased the risk for the development of endothelial dysfunction, micro- and macrovascular complications.”

“Based on our results we can conclude that administration of both vanadium and insulin reduced the low-grade systemic inflammation in T2DM, through reduction of both proinflammatory cytokines and adhesion molecules and increase adiponectin.”

“Concomitant administration of insulin and vanadium significantly improved the above measured parameters compared to either insulin or vanadium treatment.”

“Concomitant treatment with insulin and vanadium resulted in a significant improvement in all the measured parameters compared to each alone.”

“ Vanadium , as a trace element with insulin mimetic effect, may act synergistically with insulin to protect against the development of DN.”

“ Vanadium treatment of non-diabetic animals lowers plasma insulin levels by reducing insulin demand, as these animals remain normoglycemic.”

“ Vanadium treatment resulted in decreased insulin levels and improved insulin sensitivity in the fatty rats.”

“These results indicate that vanadium metabolism varies widely among different organs, and that insulin , either directly or indirectly has effects on the retention of vanadium.”

“This may have impact on the therapeutic use of vanadium in Type I diabetics with no insulin , or Type II patients who may be relatively hyperinsulinemic.”

“ Vanadium , a potent nonselective inhibitor of protein tyrosine phosphatases, has been shown to mimic many of the metabolic actions of insulin both in vivo and in vitro.”

“This observation deserves consideration in view of the potential clinical application of vanadium treatment to mimick insulin action and lower blood glucose.”