Possible Interaction: Insulin and Valine

“To reduce the generation of insoluble calcium salts and relieve the disease symptoms, the intake of valine needs to be restrained.”

“As expected, the infusion of insulin exhibited significant reduction of the release of glycine, proline, valine , phenylalanine, leucine, threonine and isoleucine.”

“ Insulin (10(-6) M) and IGF-I (10(-9) M) increased (p less than 0.01) incorporation of radiolabeled thymidine, uridine, and valine.”

“Isoleucine and valine showed a negative correlation with insulin.”

“ Insulin significantly increased the ileal uptake of valine , isoleucine, leucine, tyrosine, threonine, and serine from arterial blood: uptake of these amino acids was approximately doubled 45 min after the end of the insulin infusion.”

“In adipocytes from fed rats, the rate of fatty acid synthesis in the presence of glucose and insulin was inhibited 40% by valine (5 mm).”

“Pyruvate output into the incubation medium from fat pads obtained from fed rats and incubated with glucose and insulin was decreased significantly by the addition of valine.”

“Protein synthesis in isolated diabetic liver cells as measured by the incorporation of radioactive isoleucine, valine and phenylalanine into protein decreases (5–6 fold) with time after insulin withdrawal.”

“The results showed that valine treatment markedly increased serum triglyceride and insulin levels of chow diet-fed mice.”