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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Conclusion: Insulin inhibits retinoic acid biosynthesis through inhibition of FoxO1-induced Rdh10 gene expression.”
“Results: Refeeding, glucose, and insulin decrease retinoic acid in vivo.”
“Significance: Insulin and retinoic acid exert counter balancing effects in regulating energy status.”
“These results reveal mechanisms for regulating atRA biosynthesis and the opposing effects of atRA and insulin on gluconeogenesis, and also suggest an interaction between atRA and insulin signaling related diseases, such as type II diabetes and cancer.”
Insulin Regulates Retinol Dehydrogenase Expression and All-trans-retinoic Acid Biosynthesis through FoxO1*“ All-trans retinoic acid , a derivative of vitamin A, reverses these effects, resulting in increased insulin sensitivity, suppression of the phosphoenolpyruvate carboxy kinase (PEPCK) gene, and the induction of the glucokinase gene.”
“In human islets of Langerhans, retinoic acid was shown to stimulate insulin mRNA levels.”
“ Insulin suppresses both basal and retinoic acid‐induced IGFBP‐2 mRNA expression in hepatocytes and has no such effect on osteoblasts.”
“ Insulin inhibits ATRA biosynthesis through inhibition of FoxO1-induced RDH gene expression (s21) (Fig. 1a).”
“The specific sensitivity of the E2-dependent cell lines seems not to be caused by an inhibitory effect of RA on ER functioning since RA inhibited the proliferative response not only to E2 but also to insulin.”
“Increases in glycogen content were induced by insulin , and was further enhanced in the presence of RA.”
“ RA acted synergistically with insulin to phosphorylate glycogen synthase kinase 3β, and dephosphorylate glycogen synthase (GS), which was associated with increases in the protein and mRNA levels of GS.”
“ RA acted synergistically with insulin to reduce glucose and pH levels in the medium.”
Long-term treatment with insulin and retinoic acid increased glucose utilization in L6 muscle cells via glycogenesis.“In previous investigations, treatment with retinoic acid was found to be associated with enhanced insulin sensitivity.”
“Dietary administration of all‐trans‐retinoic acid (ATRA) significantly improved insulin sensitivity in C57BL/6J mice, which served as a model for high‐fat, high‐fructose diet–induced nonalcoholic fatty liver disease (NAFLD).”
“We have reported that retinoids synergized with insulin to induce the expression of sterol-regulatory element-binding protein 1c gene (Srebp-1c) expression in primary rat hepatocytes.”
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