supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Insulin
supplement:
Sulforaphane
Research Papers that Mention the Interaction
“We conclude that SFA recovers glucose homeostasis and improves insulin sensitivity by blocking ceramide biosynthesis through modulating SPTLC3, indicating that SFA may be a potential candidate for prevention and amelioration of hepatic insulin resistance via a ceramide-dependent mechanism.”
Sulforaphane Prevents Hepatic Insulin Resistance by Blocking Serine Palmitoyltransferase 3-Mediated Ceramide Biosynthesis“Furthermore, SFN and PIO administrations improved insulin resistance-associated heaptosteatosis and enhanced vascular responsiveness to acetylcholine-induced relaxations.”
Comparison of the effects of sulforaphane and pioglitazone on insulin resistance and associated dyslipidemia, hepatosteatosis, and endothelial dysfunction in fructose-fed rats.“A more detailed knowledge on the direct interaction of SFN with insulin and its binding sites is necessary for better understanding the role of SFN on diabetes.”
“ SFN is found to bind covalently with the free NH2 group of the N-terminal of the A and B chains of insulin.”
“The in-source fragmentation experiments revealed that the SFN is binding to the NH2 groups of N-terminal amino acids of A and B chains of insulin.”
Insights into the binding sites of sulforaphane on insulin studied by electrospray ionization mass spectrometry.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback