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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Insulin
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“Cell treatment with S1P at 0.1-5.0 μM reversed the effects of high insulin concentrations on ROS generation, glucose uptake, and insulin signaling.”
Hepatic insulin resistance induced by mitochondrial oxidative stress can be ameliorated by sphingosine 1-phosphate“S1P stimulated VEGF-A secretion in both cell lines, and blocking S1P receptors 1, 2 and 3 attenuated the S1P-evoked secretion …. Neither TSH nor insulin affected the amount of secreted VEGF-A or -C in ML-1 cells, while simultaneous stimulation with insulin … S1P increased VEGF-… FRO cells.”
“Ceramides, hexosylceramides, and sphingosine-1-phosphate significantly heightened by palmitate correlated negatively with insulin sensitivity and positively with pro-inflammatory indices.”
Sphingolipid changes do not underlie fatty acid-evoked GLUT4 insulin resistance nor inflammation signals in muscle cells[S]“ S1P per se did not affect the proliferation of the cells, but attenuated the proliferation evoked by a combination of insulin and TSH.”
“ S1P alone was a weak inducer of DNA synthesis, but its effects were enhanced by phosphocholine (PCho), insulin , ATP or PMA.”
“However, S1P is enhanced by various growth factors including EGF, IGF-1, and insulin , which activate the S1P kinase, SphK1 (12).”
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