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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“Subgroup analyses indicated that insulin (which was negative in overall analysis) was significantly decreased in patients undergoing silymarin monotherapy (SMD: −2.03, 95% CI = [−3.03, −1.04]; P = .044) for more than 3 months (SMD: −0.01, 95% CI = [−0.25, −0.24]; P = .035).”
The therapeutic effects of silymarin for patients with glucose/lipid metabolic dysfunction“Our results revealed that supplementation with silymarin can decrease fasting blood sugar, hemoglobin A1C, insulin , low-density lipoprotein cholesterol and malondialdehyde and increase high-density lipoprotein cholesterol levels.”
“ SMN significantly reduced the FBS level, increased the concentration of insulin and improved HOMA-IR.”
Silymarin ameliorates expression of urotensin II (U-II) and its receptor (UTR) and attenuates toxic oxidative stress in the heart of rats with type 2 diabetes.“The declined levels of insulin were enhanced again after treatment of diabetic rats with silymarin , reflecting a restoration of the pancreatic β-cells activity.”
“The overall results suggest that silymarin induces pancreatic function recovery demonstrated by insulin and glucagon expression protein and normoglycemia after alloxan pancreatic damage in rats.”
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