Possible Interaction: Insulin and Selenium

“ Selenium exposure can induce liver insulin resistance and increased liver triglyceride concentrations in animals, which may link to an increased risk of nonalcoholic fatty liver disease (NAFLD).”

“Metformin did not have any … or insulin sensitivity, but fasting insulin concentrations decreased ….1 ( SE ) to 29.8 +/- 4.3 pmol/liter (P = 0.03), the waist to hip ratio decreased from ….01 to 0.75 +/- 0.01 (P = 0.01), and hepatic insulin clearance increased during the treatment.”

“In conclusion, dietary Se oversupply may affect expression and activity of proteins involved in energy metabolism in major insulin target tissues, though this is probably not sufficient to induce diabetes.”

“…,selenium …), insulin (β, − 1.14 μIU/mL; 95% CI, − 2.01, − 0.28; P = 0.01); homeostasis model of assessment-estimated insulin resistance (HOMA-IR) (β − … significantly increased HDL-cholesterol levels (β, 2.72 mg/dL; 95% CI, 0.89, 4.55; P = 0.005) compared with the placebo.”

“For patients prescribed insulin at baseline (n = 80), TDD was significantly reduced at all visits (p < 0.0001), with mean ± SE reduction of 17 ± 4.5 units/day at 14 months.”

“Overall, this meta-analysis showed that selenium administration may lead to an improvement in insulin and QUICKI, but did not affect FPG, HOMA-IR, and lipid profiles.”

“Also, selenium supplementation resulted in marginally significant increase (p=0.056) in insulin level when compared with the placebo group.”

“OBJECTIVE In this study, we investigated whether insulin and selenium in combination (In/Se) suppresses cardiomyocyte apoptosis and whether this protection is mediated by Cbl-b regulating p38MAPK/CBP/Ku70 pathway.”

“ Se inició tratamiento con insulina.”

“The evidence that insulin and glycaemia influence the transport and activity of Se , via regulatory activity on selenoproteins, and that high serum Se may have a diabetogenic effect suggests a ‘Janus-effect’ of Se in T2DM.”