Possible Interaction: Insulin and Secretin

“This joint action of insulin and secretin may have a physiological role in the immediate postprandial period.”

“The identity of this hormone remains speculative, but the intestinal hormones secretin (Pfeiffer et al., 1965; Dupr6 et al., 1966; Unger et al., 1966b), pancreozymin (Ketterer et al., 1966), and glucagon (Samols et al., 1965a, 1965b) have all been reported to stimulate the release of insulin.”

“Gastrointestinal hormones secretin , CCK-PZ, gastrin, and serotonin) modulate the glucose- and amino acids–induced secretions of insulin and glucagon, respectively.”

“These studies suggest that secretin participates in the augmentation of insulin release after oral stimuli, and that a rapid sequence of humoral events takes place, gastrin releasing secretin and secretin releasing insulin.”

“Research in animals suggests that brain insulin action influences pancreatic insulin secretion.”

“In parallel, plasma insulin concentration increased to 365 +/- 51 pmol/l 2 minutes after secretin.”

“of secretin provokes a secretion of insulin that is weak and brief compared to that provoked by glucose; thus secretin fails to potentiate arginine-induced insulin secretion.”

“Intravenous injection of the gastro-intestinal hormone secretin elicits an increase in the insulin concentration in the cubital vein.”

“By comparison with effects of glucose alone each secretin infusion enhanced the increments of immunoreactive insulin in the blood.”

“The intravenous injection of ten unit of secretin during the infusion of glucose caused a greater rise in plasma insulin level and a more marked decrease in blood glucose concentration than either the infusion of glucose or secretin alone did, resulting in a significant increase in the insulinogenic index.”