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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
Research Papers that Mention the Interaction
“In this study, we observed that 1% saponin can increase the blood concentration of insulin fivefold higher than that without saponin.”
Combination of Two Sulfonylureas“Although ocular instillation of insulin alone did not decrease the serum glucose concentration, instillation of insulin with absorption promoters such as EDTA and saponin decreased it.”
Effect of Preservatives on Systemic Delivery of Insulin by Ocular Instillation in Rabbits“ Saponin , Brij-78, BL-9 and several alkylglycosides all increased the systemic absorption of insulin following delivery in eyedrops.”
“The site of insulin absorption appears to be the nasolacrimal drainage system of the rat because administration of a solution containing insulin plus saponin directly into the punctum caused a rapid, significant decrease in blood D-glucose levels.”
“These results indicate that the systemic absorption of 1% insulin through the eyes can be enhanced at least 7-fold when 1% of the surfactant, saponin , was added to the solution.”
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