Possible Interaction: Insulin and Quercetin

“Importantly, we show that oral administration of quercetin significantly increased brain apoE and reduced insoluble Aβ levels in the cortex of 5xFAD amyloid model mice.”

“The results demonstrated that quercetin dose-dependently inhibited amyloid formation of insulin.”

“In WKY rats, quercetin in vitro and in vivo, impaired the relaxation to insulin.”

“In clinic,some classical oral hypoglycemic agents and diuretic including metformin,rosiglitazone,glibenclamide,… spironolactone,as well as some extracts from Chinese herbal medicines including astragalus polysaccharides quercetin ,puerarin,emodin,berberine,curcumin … can both affect insulin and its receptor activity,and regulate IR-… pathways,thereby ameliorating IR and CKD progression.”

“ Quercetin reduces serum glucose, insulin , triglycerides, and cholesterol levels and increases the expression and secretion of adiponectin.”

“ Quercetin (10 μM) increased cell proliferation by 3.05 folds with decreased TAG content (45%) and was effective in increasing insulin mediated glucose uptake by 2.65 folds.”

“On the other hand, insulin like growth factor1, integrin αvβ3, and cyclooxygenase2 mRNA expression in the uterus of diabetic mice were significantly reduced, and quercetin treatment augmented the expression level of these genes.”

“ Quercetin treatment significantly lowered insulin and IR expression and significantly enhanced GLUT-4 and DCX expression in the hippocampus, when compared to CUS.”

“Treatment … quercetin showed statistically significant (p <….01) improvement in insulin (12.46 ± 0.3 versus 10.0 ± 0.28 μU/ml), testosterone (0.65 ± 0.02 versus 0.29 ± 0.02 μU/ml), luteinising hormone (20.6 ± 0.28 versus 15.1 ± 0.36 U/ml), and lipid profile.”

“SCOPE Quercetin is a dietary flavonoid whose role in the regulation of the activity of insulin remains controversial.”