Possible Interaction: Insulin and Progesterone

“A significant negative correlation was observed between insulin and progesterone (r = -0.60; P < 0.01) and between progesterone and LH (r = -0.56; P < 0.05) concentrations, and a positive correlation (r = 0.83; P < 0.001) was observed between LH and insulin.”

“The results suggest that hyperinsulinemia/insulin resistance may be responsible for low progesterone levels during the luteal phase in PCOS.”

“LH, total testosterone, and insulin levels may be affected from the short-term progesterone treatment.”

“ Progesterone administration enhances glucose-stimulated insulin production in both monkeys and man.”

“Recent studies have shown that insulin regulates placental lactogen, progesterone , and estrogen production from human trophoblast cells.”

“We conclude that insulin and LDL synergistically enhance progesterone biosynthesis by swine granulosa cells via specific mechanisms that depend upon 1,2,-cyclohexanedione-sensitive residues within LDL apoprotein.”

“Gestamimetic amounts of progesterone enhance basal and glucose-stimulated insulin production.”

“By contrast, progesterone administration (5 mg daily in olive oil sc×3 weeks) led to significantly increased mean SI40 and mean initial rate of insulin release (Δl⁄ΔG10) in association with significantly slower mean glucose disappearance rate after iv glucose.”

“ Progesterone was inversely associated with fasting insulin (β=−0.047, 95% CI −0.088 to −0.006) and positively associated with QUICKI (β=0.041, 95% CI 0.001 to 0.082).”

“When menopause occurs as a result of hysterectomy, then the hormones such as estrogen and progesterone affect how the body cells respond to insulin.”

“Studies suggest that insulin treatment increases progesterone and androstenedione secretion in PCOS theca cells when compared to insulin treated normal theca cells.”