Possible Interaction: Insulin and Polyunsaturated Fatty Acids

“The FFA pattern low in polyunsaturated FFAs reduced insulin sensitivity more than the pattern high in polyunsaturated FFAs.”

“Among polyunsaturated fatty acids (PUFA) there is some, but not conclusive, evidence that ω-3 (n−3) PUFA may play a particular role in improving insulin action ; certainly a high n−6/n−3 ratio appears deleterious.”

“In contrast, polyunsaturated fatty acids increase plasma insulin concentration and decrease insulin resistance.”

“ Long chain polyunsaturated fatty acids (LCPUFAs) increase … of insulin to its receptors; suppress TNF-alpha, IL-6, macrophage migration inhibitory factor (MIF) and leptin synthesis; increase the number of … regulate the balance between pro- and anti-oxidants, and thus, play a critical role in the pathogenesis of insulin resistance.”

“In contrast, PUFA increase plasma insulin concentration and decrease insulin resistance.”

“… polyunsaturated fatty acids (… insulin The plasma levels and tissue content of TG are determined by the balance between de novo synthesis of fatty acids (and consequently of …).I8-z0 Thus, a defect at any step of this enzyme network may initiate a cascade of pathological events leading to hypertriglyceridemia.”

“ Polyunsaturated fatty acid consumption has been shown to improve insulin sensitivity.”

“The synergism between PUFA , MUFA, polyphenols and carotenoids present in pistachios can modulate specific miRNA, increasing insulin sensitivity through the PI3K-AKT signaling pathway.”

“Low-ratio n-6/n-3 PUFA supplementation could reduce the plasma insulin level when the supplementation duration was longer than 8 weeks.”

“In dose–response analyses, … energy (En%) from PUFA … insulin by 5.8 pmol/L (95% CI −10.2 to −1.3 pmol/L), but not glucose (change −0.07, ….17 to 0.04 mmol/L) and HOMA-IR (change − 0.24, 95% CI −0.56 to 0.07 units).”

“In subgroup analyses, … with higher PUFA dose (upper …) reduced insulin (-6.7, –10.5 to −2.9 pmol/L) and HOMA-IR (-0.28, –0.45 to −0.12 units), … not glucose (−0.09, 95% CI −0.18 to 0.01 mmol/L), as compared with an isocaloric control.”