Possible Interaction: Insulin and Polyphenols

“These beverages include compounds that may have contradictory effects on insulin and glucose: Caffeine impairs insulin sensitivity, but polyphenolic molecules within tea, coffee, and cocoa augment the effects of insulin.”

“Finally, simvastatin and the polyphenol quercetin potentiated the antiproliferative effect of insulin ; on the contrary, the polyphenol resveratrol, the polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids, and folic acid were not able to change it.”

“The positive correlation between the level of polyphenol intake and insulin level warrants further studies on the effect of green tea on insulin resistance.”

“Within the intervention group, changes in insulin level tended to be associated with changes in polyphenol intake.”

“ TP reduced serum total cholesterol, triglyceride, low density lipoprotein, glucose (GLU) and insulin ( INS ) levels of HFD mice in a dose-dependent manner (P < 0.01).”

“SIRT1 activators, including plant polyphenols such as resveratrol, improve insulin sensitivity in skeletal muscle tissue.”

“In summary, our study showed that polyphenols are able to prevent cardiac hypertrophy and production of reactive oxygen species in the insulin resistant fructose-fed rat.”

“Finally, simvastatin and the polyphenol quercetin potentiated the antiproliferative effect of insulin ; on the contrary, the polyphenol resveratrol, the polyunsaturated fatty acids eicosapentaenoic and docosahexaenoic acids, and folic acid were not able to change it.”

“As a result, compared to the high-fat diet group, increases in body weight, plasma glucose and insulin were significantly suppressed for AP groups.”

“These polyphenolic polymers found in cinnamon may function as antioxidants, potentiate insulin action , and may be beneficial in the control of glucose intolerance and diabetes.”