Possible Interaction: Insulin and Polypeptides

“The postprandial rise in insulin was also delayed by PP.”

“Co-release of polypeptides and hormones like insulin requires further expansion of the pore.”

“SummaryA two-chain polypeptide , which corresponds to amino acid residues 115–143 and 144–184(185) of bovine serum albumin, connected to each other by a disulfide bridge, potentiated the effects of insulin on glucose transport and glucose metabolism in isolated rat adipocytes.”

“In conclusion, insulin-mediated DNA-protein binding has been identified on the upstream hGH promoter, suggesting a trans-active role for insulin in mediating polypeptide hormone gene expression.”

“The data obtained previously … have evidenced that pineal polypeptide factors enhance the sensitivity of the hypothalamo-hypophyseal complex to the inhibiting action of … and show an antistressor effect and the capacity to decrease the level of insulin and triglycerides in the experiment, and … growth of transplantable mammary gland cancer.”

“Fasting plasma concentrations of insulin increased by 120% ± 15% (P = 0.02), glucagon-like peptide 1 (GLP-1) by 60% ± 20% (P < 0.01), and Polypeptide YY(3-36) by 80% ± 30% (P < 0.02) after cycling.”

“Conclusions: A concurrent subcutaneous infusion of PP enhances insulin sensitivity and reduces insulin requirements in patients with long-standing T1DM and T3cDM on insulin pump therapy.”

“This may be due to the negative feedback effect of insulin on the production of these polypeptides.”

“Intravenous infusion of PP corrected the hepatic resistance to insulin seen in the PP-deficient group.”

“SummaryVasoactive intestinal polypeptide is a pancreatic neurotransmitter which augments insulin release.”